During treatment, patients need to control Agus anavar for sale symptoms. Recommended lifelong treatment with the exception of those cases when there are medical indications for the cessation of treatment. For intravenous administration, the diluted solution is necessary to use special infusion systems with controlled delivery. It is not necessary to protect the diluted solution of the drug from light during administration.
After administration observation of the patient should be continued for 1 hour. If adverse events develop during administration of the drug, the infusion rate can be reduced down to a complete stop on the introduction of the physician’s discretion. By reducing the speed of administration , the total infusion time should not exceed 2:00 for adults and children aged 12 to 18, and 4:00 – for children under 12 years. Features of the application in selected patient groups Elderly patients The drug can be administered to patients over 65 years. Elderly patients No special dosage regimen and compliance with special precautions, although the clinical experience of treating this age group of patients is limited. Use in patients with impaired renal function dose adjustment Soliris drug in patients with renal impairment is not required. Use in patients with impaired hepatic function Special research on the effectiveness and safety in patients with impaired liver function is not carried out (see. section “Precautions).
The most common adverse event in the treatment ekulizumabom was headache (observed mainly in the initial cycle of therapy). The most serious adverse event was meningococcal septicemia.
The following are a summary of the adverse reactions identified in clinical studies and in post-marketing period in patients with and Agus receiving ekulizuma. Violations of the blood and lymphatic system: Often – leukopenia, thrombocytopenia, hemolysis; * Uncommon – coagulopathy, agglutination of red blood cells, coagulation disorders, anemia, lymphopenia.
Benign, malignant and unspecified neoplasms: Uncommon anavar for sale – myelodysplastic syndrome, melanoma. violations of the heart: Infrequent – palpitation sensation. violations by vessels: Often – lowering blood pressure; Infrequently hematoma, hypertension, malignant hypertension, “tides” of blood, venous disease. violations of the organ of hearing and labyrinth disorders:Uncommon – ringing in the ears, vertigo (vestibular vertigo). by the violations endocrine system: Infrequent – hyperthyroidism. Violations of the organ of vision: Uncommon – irritation of the conjunctiva, blurred vision.
Violations of the gastrointestinal tract: often – abdominal pain, constipation, diarrhea, dyspepsia, nausea, vomiting Uncommon – bloating, gastroesophageal reflux disease, pain in the gums, peritonitis. Violations of the metabolism and nutrition: often – decreased appetite, not often – anorexia. Violations of the liver and biliary tract: Uncommon – jaundice. Disorders of the nervous system:very often – headache; Often – peripheral dizziness, dysgeusia. Uncommon – syncope, tremor, paresthesia. Violations of the respiratory system, organs, thoracic and mediastinal disorders: often – cough, swelling of the mucous membranes of the nose, pain in the larynx and pharynx, dyspnea, rhinorrhea, not often – hemoptysis, sore throat. mental disorders: Infrequent – abnormal dreams, anxiety, depression, insomnia, mood swings, sleep disturbances. violations of the kidney and urinary tract: uncommon – haematuria, renal impairment, dysuria. violations of the skin and subcutaneous tissue disorders: Often – alopecia, pruritus, rash, Uncommon – urticaria, dermatitis, erythema, petechiae, violation of skin pigmentation, hyperhidrosis, dry skin. Violations of the musculoskeletal and connective tissue disorders: often – arthralgia, back pain, myalgia, pain in the neck , pain in the limbs, bone pain, muscle spasms, not often – swelling of the joints, lockjaw.
Infectious and parasitic diseases: Often – upper respiratory anavar for sale tract infections, urinary tract infections, including viral, nasopharyngitis, bronchitis, herpes oral mucosa, meningococcal sepsis, bacterial arthritis, aspergillosis; Infrequent – infections of the lower respiratory tract, gastrointestinal tract, cystitis, sinusitis, infections of dental tissues and gums, abscesses and inflammation of the subcutaneous tissue, fungal infection, influenza, of Neisseria infection and of Haemophilus, impetigo, meningococcal meningitis, sepsis, septic shock, pneumonia. violations of the immune system: often – an anaphylactic reaction; Infrequent – hypersensitivity reactions. violations of the genital organs and the breast: Uncommon – menstrual disorders, spontaneous erection.
General disorders and in the introduction: Often – a feeling of discomfort in the chest, chills, weakness, swelling, fever, fatigue, flu-like symptoms; not often – pain in the chest, paresthesia, bruising and pain at the injection site, the feeling of “heat”. Laboratory and instrumental data: Often – positive Coombs *; not often – increasing the aspartate aminotransferase activity, increased alanine aminotransferase activity, increased activity of gamma-glutamyl transferase, decreased hemoglobin concentration and hematocrit. Injury, poisoning and procedural complications: Uncommon – non-specific reactions at the injection site * – detailed information is provided in section “Additional Information”.